Which item is required for controlled substances prescriptions?

• A. Prescriber's license number
• B. Prescriber's signature
• C. Insurance claim number
• D. Pharmacy color of sticker

Answer: (B)

A controlled-substance prescription must bear the prescriber’s signature to be valid and authorize dispensing. The signature provides legal authority and accountability that the order came from a licensed prescriber, which is essential for controlled substances. The other items—license number, insurance claim number, or pharmacy sticker color—do not prove that the prescriber actually approved the specific prescription, and thus are not the required element. In many modern systems, an electronic signature is used, but the act of signing remains the key factor that validates the prescription.